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Group B consisted of men receiving 600mg of testosterone enanthate in injection form every single weekfor 3 months, 1-4 times a week. Subjects received testosterone gel every other day in injections for 4 weeks. The last week of testosterone enanthate (TEN) was to last as long as desired by the subjects (2 weeks) before cessation of drug administration. Testosterone enanthate dose was reduced following the cessation of this cycle. Testosterone gel was administered every other day as needed to maintain hormone levels before cessation of injection. Subjects were to report to baseline once a week for 1-4 weeks, on days where TEN had been discontinued. All treatments were approved by the Institutional Review Boards (IRB's) of the University of California (San Diego, CA), the University of Texas (Rio Grande Valley, TX), and the University of Texas-Dallas. Subjects provided written informed consent to have their hormone levels tested. The data of the subjects are shown in Table 1 . The dose of testosterone in the study was determined to be the lowest possible for this population, as it was found that some men did need to receive twice or more of it than the maximum dose [ 38 ]. Testosterone gel was applied twice per day for 4 weeks to the lower extremities. When subjects reported to baseline, they were allowed to start a period of one month free to return as long as they felt as if they were sufficiently rested. To examine the long-term efficacy of any particular dose of the testosterone product, the dose was repeated 4 weeks after injection. The lowest recommended dosage was then used, as follows: 600mg of testosterone enanthate every single week for 3 months as well as at the end of treatment every other week until the subject desired to discontinue treatment (for example, the testosterone gel was changed to no more than 400mg of testosterone enanthate to be resumed on days when testosterone injection ceased). A 3-month wash out period was then initiated to determine the testosterone dose needed for the desired response. The clinical effects of TEN, while limited because of the short time spans of the study, were well described [ 26 ]. TEN was found to cause changes in heart rate, oxygen consumption rates (VO 2 ), and blood pressure. During the 4 weeks that subjects were receiving TEN there was a marked increase in VO 2 , which was significant above controls; therefore, these subjects were classified as anaerobic. During the four weeks that they were receiving TEN, VO 2 decreased as well, and in some instances (during TEN), it was significantly greater and in other cases Related Article:

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